Khader Lab

Khader Lab


S. Khadar  

Shabaana Khader

Associate Professor
khader@wustl.edu

Shabaana Khader received her PhD in Biotechnology from Madurai Kamaraj University, India where she studied host-pathogen interactions during the mycobacterial disease, leprosy. Dr. Khader then carried out her Post-doctoral training at the Trudeau Institute, NY, where she continued studying host immune responses to another globally relevant mycobacterial disease, tuberculosis. During her stay at the Trudeau Institute, Dr. Khader demonstrated a critical role for the cytokine Interleukin-17 in vaccine-induced immunity to tuberculosis, as well as described seminal roles for IL-12 cytokines in tuberculosis. Dr. Khader then joined the University of Pittsburgh in 2007 as Assistant Professor in the Department of Pediatrics where her lab continued to study the role of cytokines in immunity to intracellular pathogens such as Mycobacterium tuberculosis and Francisella tularensis. In 2013, Dr. Khader and her research team moved to the Department of Molecular Microbiology at the Washington University in St.Louis, where she is now an Associate Professor, in the Department of Molecular Microbiology.

Pubmed Publications: Khader+SA, Shabaana+AK

Office address:
Department of Molecular Microbiology
Washington University School of Medicine
Room 8210A, McDonnell Pediatric Research Building
Campus Box 8230
660 S. Euclid Ave.
St. Louis, MO 63110
Phone:(314) 286-1590
Fax:(314) 362-1232

     

   
M. Ahmed  

Dr. Mushtaq Ahmed, Ph.D.

Staff Scientist
mahmed22@wustl.edu

Dr. Mushtaq Ahmed, PhD received his PhD in Biotechnology from the School of Biotechnology, Madurai Kamaraj University, Madurai, India. He carried out postdoctoral training in the laboratory of Marcia Blackman at the Trudeau Institute, Saranac Lake, NY.  He later joined the laboratory of Dr. Sarah Gaffen, Division of Rheumatology & Clinical Immunology, University of Pittsburgh. His project aimed at deciphering the interface between pro-inflammatory cytokines and adipocyte development with special reference to the role of the inflammatory cytokine interleukin (IL)-17. Currently, his interests are targeted towards developing novel vaccines against Mtb in the laboratory of Dr. Shabaana Khader, Department of Molecular Microbiology, Washington University in St.Louis.

     

   
S. Squires  

Sarah Squires

Research Assistant
squires@wustl.edu

Sarah Squires received her B.S. in Biology with an emphasis in Chemistry from the University of Missouri. While with the University she worked in Dr. Bumsuk Hahm’s laboratory where the focus of her project was on the molecular mechanisms of how Measles virus induces, evades, and suppresses host immunity. Currently, she is working at Washington University in St. Louis under Dr. Shabaana Khader as a Research Assistant where she manages the mouse colonies and provides input on several projects within the lab.

   
     

   
Griffiths  

Dr. Shibali Das, Ph.D.

Post doctoral Fellow
sdas@wusm.wustl.edu

Shibali received her B.Sc. and M.Sc. degree in Microbiology from University of Calcutta (Kolkata, India). She then pursued her doctoral degree in Bio-chemistry at Bose Institute, under the affiliation of the University of Calcutta. Her Doctoral research focused on Immunotherapeutic approaches to tuberculosis including the development of novel immunomodulatory agents for therapy, elucidation of mechanisms of action of new therapeutic agents, mechanisms of immunosuppression during tuberculosis and regulation of host innate and adaptive immune response. In the Khader Lab, Shibali’s work is focused on identifying new ways to target the lung to improve vaccine induced immunity against tuberculosis.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=shibali+das

     

   
Kimberly Thomas  

Dr. Kimberly Thomas, PhD

Post doctoral Fellow
kimberly.a.thomas@wusm.wustl.edu

Kim received her B.S. in Biochemistry and Molecular Biology at California Lutheran University, where she engaged in research activities focused on sequencing the genome of the archaebacterium Thermoplasma acidophilum. She then moved to the southeast to obtain a Ph.D. in Microbiology from the University of Alabama at Birmingham (UAB). Her thesis work centered on characterizing the expression and function of Trem-like transcript 2 (TLT2) in the human peripheral immune compartment. Moving back to California, Kim pursued a postdoctoral position studying transplant immunology at University of California Los Angeles (UCLA). There, she studied the complement-dependent mechanisms by which donor specific antibodies mediate rejection during solid organ transplant. Combining her cellular immunity background from UAB, and alloimmunity experience at UCLA has resulted in her current interest: how the context in which antigen is seen by the immune system can dictate the specific characteristics of an immune response. To this end, Kim is interested in the requirement of antigen for induction of bronchus-associated lymphoid tissue (iBALT), as well as the mechanisms by which antigen presenting cells sustain iBALT, during tuberculosis.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/Thomas

     

   
domingo-gonzalez  

Dr. Racquel Domingo-Gonzalez

Postdoc Research Associate
rdomingo@wustl.edu

Racquel Domingo-Gonzalez obtained her bachelors in science degree at the University of California in Santa Barbara in Microbiology. Following her undergraduate studies, she pursued her doctoral degree in Immunology at the University of Michigan. There, she characterized the functional defects in alveolar macrophages and neutrophils following bone marrow transplantation. Currently, her research focuses on understanding the role of neutrophils in granuloma formation.

     

   
Prince  

Dr. Oliver Prince

Postdoc Research Associate
princeo@wustl.edu

Oliver received his B.Sc. in biology from St. Francis College (Brooklyn, NY) and his M.Sc. in medical microbiology from Long Island University (Brooklyn, NY). He joined the lab of Duncan C. Krause at the University of Georgia (Athens, GA) where he was awarded his Ph.D. in microbiology for studies in Mycoplasma pneumoniae colonization of the human airway. Currently, Oliver is interested in the arms race at the interface between Mycobacterium tuberculosis and the human host. Specifically, he is focused on the factor(s) of M. tuberculosis that dictate the host immunological response and mediate its own survival and avoid clearance.  

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=prince+oa

     

   
treerat  

Ninecia Scott

DBBS Graduate Student
ninecia.scott@go.wustl.edu

Ninecia attended North Carolina Central University were she received her BS degrees in Biology and Pharmaceutical Sciences. She is currently a graduate student within the Molecular Microbiology and Microbial Pathogenesis program. Ninecia current project explores the role neutrophils play in Tuberculosis.

     

   
treerat  

Nicole Howard

DBBS Graduate Student
nhoward@go.wustl.edu

Nicole Howard received her bachelor’s degree in Biochemistry & Cell Biology from Rice University. She is a first year graduate student in the Molecular Microbiology and Microbial Pathogenesis program. Her current project looks at Mycobacterium tuberculosis pathogenesis within the central nervous system.

     

   
treerat  

Micah Dunlap

Graduate Student
dunlapmicah@wustl.edu

Micah was trained in Biochemistry at the University of North Carolina at Chapel Hill, where he did research in organic chemistry in chiral compound synthesis. One summer he took an internship at the NIH, where he worked on testing out a new hydrogel material to be used for DNA and TLR agonist based vaccines for melanoma. His project in the Khader Lab is to better understand the role of chemokines in immune responses to tuberculosis.

     

   
Nancy  

Nancy Marin-Agudelo, PhD


nmarinagudelo@wustl.edu

Nancy Marin-Agudelo obtained her B.S. in Bacteriology and Clinical Laboratory (now Microbiology) at the Microbiology School, University of Antioquia, Colombia. She pursued her doctoral degree in Biomedical Science with emphasis immunology from the same university in Colombia. During this time, her study was focused on the T cells regulation, mainly on Th1, Th17 and regulatory T cells subsets, in latently infected individuals and patients with active TB. After receiving her PhD, she joined as a temporary professor to the school of medicine, University of Cauca and to the Microbiology School, University of Antioquia in Colombia where she was studying the role of T cells co-stimulation in the anti-mycobacterial immune response. Nancy is interested on identifying new ways to target the host immune response to improve vaccine induced immunity against tuberculosis.

     

   
Mehta  

Shail Mehta, M.D.


sbmehta@wustl.edu

Shail Mehta, M.D. completed an internal medicine residency at the University of Michigan in 2011. Prior to fellowship, worked on the Navajo Nation in Shiprock, NM for four years providing full-spectrum internal medicine care, including treatment of patients with mycobacterial disease. He is 2nd year Pulmonary-Critical Care fellow at Barnes-Jewish hospital with a clinical and research interest in non-tuberculous mycobacterial disease. The research is funded by the T32 pulmonary training grant.

^top