Khader Lab


Photo 1:
T cell localization within ectopic lymphoid tissues: an immunological traffic light. During Mycobacterium tuberculosis infection, absence of the chemokine CXCL-13 results in arrest of T cells (red) in the perivasculature of the lung. Upon CXCL-13 expression (yellow), however, CXCR5-expressing T cells migrate into the lung parenchyma and mediate formation of ectopic lymphoid tissues (green), a process that is required for macrophage activation and immune control of Mycobacterium tuberculosis. Artistic representation by Leticia Monin.