Khader Lab


PDF reprints are available on selected papers. Access by clicking highlighted titles.


Ahmed M, Jiao H, Domingo-Gonzalez R, Das s, Griffiths KL, Rangel-Moreno J, Nagarajan UM, and Khader SA. Rationalized design of a mucosal vaccine protects against Mycobacterium tuberculosis challenge in mice. Journal of Leucocyte Biology FEBRUARY 15, 2017. DOI: 10.1189/jlb.4A0616-270R)

P Treerat,O Prince, A Cruz-Lagunas, M Mun˜oz-Torrico, MA Salazar-Lezama, M Selman,B Fallert-Junecko, TA Reinhardt, JF Alcorn, D Kaushal, J Zun˜iga, J Rangel-Moreno, JK Kolls and SA Khader. Novel role for IL 22 in protection during chronic Mycobacterium tuberculosis HN878 infection. Mucosal Immunol.  2017 Mar 1. doi: 10.1038/mi.2017.15. PMID:28247861


Racquel Domingo-Gonzalez, Oliver Prince, Andrea Cooper, and SA. Khader. Cytokines and Chemokines in Mycobacterium tuberculosis Infection. Microbiol Spectr. 2016 Oct;4(5). DOI: 10.1128/microbiolspec.TBTB2-0018-2016 PMID: 27763255

Kristin L. Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D. Connell,Kelly D. Moynihan, Jay K. Kolls, Darrell J. Irvine, Maxim N. Artyomov, Javier Rangel-Moreno & Shabaana A. Khader. Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy. Published 22 Dec 2016 DOI: 10.1038/ncomms13894

S.R. Gish, E.J.Maier, B.C.Haynes, F.H.Santiago-Tirado, D.L. Srikanta, C.Z. Ma, L.X. Li, M.Williams, E.C. Crouch, S.A. Khader, M.R. Brent, and T. L. Doering. Computational analysis reveals a key regulator of cryptococcal virulence and determinant of host response. mBio, 2016 Apr 19;7(2). pii: e00313-16. doi: 10.1128/mBio.00313-16.

V.Lampropoulou, A.Sergushichev, M.Bambouskova, S.Nair, E.Vincent, E.Loginicheva, L.Cervantes-Barragan, X.Ma, S.Ching-Cheng Huang, C.J. Weinheimer, S.Khader, G.J. Randolph, E.J.Pearce, R.G.Jones, A.Diwan, M.S. Diamond, M.N. Artyomov. Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Cell Metabolism, 2016 Jul 12;24(1):158-66. doi: 10.1016/j.cmet.2016.06.004. Epub 2016 Jun 30.

K.L.Griffiths, D.O.Villarreal, D.B. Weiner, S.A. Khader. A novel multivalent tuberculosis vaccine confers protection in a mouse model of tuberculosis. Human Vaccines and Immunotherapeutics. 2016 Jun 20:0.



L.Monin, K.Griffiths, S.Slight, Y.Lin, J.Rangel-Moreno, S.A. Khader. Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge. Mucosal Immunol. 2015 Jan 28. doi: 10.1038/mi.2014.136.

S.Mehra, T.W. Foreman, P.J. Didier, M.H. Ahsan, T.A. Hudock, R.Kissee2, N.A.Golden, U.S. Gautam, X.Alvarez, K.E.Russell-Lodrigue, L.A. Doyle, C.J.Roy, J.L.Blanchard, S.A.Khader, A,A.Lackner, D.R.Sherman, D.Kaushal. The DosR regulon modulates adaptive immunity and is essential for M. tuberculosis persistence. American Journal of Critical Care Medicine, Am J Respir Crit Care Med. 2015 May 15;191(10):1185-96. A special commentary highlighting this paper appeared in the same issue “Toward Resolving the Paradox of the Critical Role of the DosR Regulon in Mycobacterium tuberculosis Persistence and Active Disease” by Martin I. Voskuil and Larry S. Schlesinger.

L.Monin, KL.Griffiths, WY.Lam, R.Gopal, DD.Kang, M.Ahmed, A.Rajamanickam, A.Cruz-Lagunas, J. Zúñiga, S. Babu, JK.Kolls, M.Mitreva, B.A.Rosa, R.Ramos-Payan, T.E. Morrison, PJ. Murray, J. Rangel-Moreno, EJ. Pearce and S.A.Khader. Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis. J Clin Invest. 2015 Nov 16. pii: 77378. doi: 10.1172/JCI77378.

D.Kaushal, T.W. Foreman, T.Adekambi, U.S.Gautam, J.Rangel-Moreno, N. A. Golden, A.F. Johnson, B.L.Phillips,  K.E.Russell-Lodrigue, L.A.Doyle, P.J. Didier,  J.L. Blanchard, J.Rengarajan, A.A.Lackner, S.A.Khader, S.Mehra. Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects macaques against lethal tuberculosis. Nat Commun. 2015 Oct 13;6:8533. doi: 10.1038/ncomms9533.



B.L.Phillips, S.Mehra, M.H.Ahsan, M.Selman, S.A.Khader, D.Kaushal. LAG-expression in active Mycobacterium tuberculosis infections. American Journal of Pathology, 2014 Dec 27. pii: S0002-9440(14)00671-3. doi: 10.1016/j.ajpath.2014.11.003.

L.Monin, K.Griffiths, S.Slight, Y.Lin, J.Rangel-Moreno, S.A. Khader. Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge. Mucosal Immunol. 2015 Jan 28. doi: 10.1038/mi.2014.136.

S.A.Khader* and J.K.Kolls*. Editorial overview: Vaccines for infectious diseases: Are we there yet? Curr Opin Immunol. 2014 Jun;28:ix-x. doi: 10.1016/j.coi.2014.03.005. Epub 2014 Apr 12.

L.Monin and S.A.Khader*. Chemokines in tuberculosis: The Good, the bad and the ugly. Seminars in Immunopathology. 2014 Dec;26(6):552-8. doi: 10.1016/j.smim.2014.09.004.

K.Griffiths and S.A.Khader*. Bringing in the cavalry: IL-26 mediates neutrophil recruitment to the lungs. American Journal of Respiratory and Critical Care Medicine. Am J Respir Crit Care Med. 2014 Nov 15;190(10):1079-80. doi: 10.1164/rccm.201410-1870ED.

R.Gopal, L.Monin, S.Slight, U.Uche, E.Blanchard, B.Fallert Junecko, R. Ramos-Payan, C.L.Stallings, T.A.Reinhart, J.K.Kolls, D.Kaushal, U.Nagarajan, J.Rangel-Moreno and S.A. Khader*. Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection. PLoS Pathog. 2014 May 15;10(5):e1004099. doi: 10.1371/journal.ppat.1004099. eCollection 2014 May.

Kristin Griffiths and S.A.Khader*. Novel vaccine approaches for protection against intracellular pathogens. Curr Opin Immunol. 2014 Jun;28C:58-63. doi: 10.1016/j.coi.2014.02.003. Epub 2014 Mar 6.

R.Gopal, J.Rangel-Moreno, B.Fallert Junecko, D.Mallon, K.Chen, D.Pociask, T.D. Connell, T.A.Reinhart, J.F.Alcorn, T.M.Ross, J.K.Kolls, and S.A.Khader*. Short Communication: Mucosal pre-exposure to Th17-inducing adjuvants exacerbates pathology following influenza infection. American Journal of Pathology. Oct 31. doi:pii: S0002-9440(13)00667-6. 10.1016/j.ajpath.2013.09.012. [Epub ahead of print].



R.Gopal, J.Rangel-Moreno, S.Slight, Y.Lin, H.F.Nawar, B.A. Fallert Junecko, T.A. Reinhart, J.Kolls,T.D. Randall, T.D. Connell and S.A. Khader*. Interleukin-17-dependent CXCL-13 mediates mucosal vaccine-induced immunity against tuberculosis. Mucosal Immunology. 2013. 6, 972–984. Highlighted as a featured article in the journal.

Slight SR, Rangel-Moreno J, Gopal R, Lin Y, Fallert Junecko BA, Mehra S, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Pavon L, Kaushal D, Reinhart TA, Randall TD, Khader SA*. CXCR5+ T helper cells mediate protective immunity against tuberculosis. Journal of Clinical Investigation. 2013. Feb 1: 123 (2):712-726.

N.Obermajer, J.Wong, R.P.Edwards, K.Chen, M.Scott, S.A.Khader, K.Odunsi, T.R.Billiar and P.Kalinski. Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling. Journal of Experimental Medicine. 2013, 210:1433-1445.

N.Hernandez-Santos, A.C. Peterson, A.R. Huppler, S.A. Khader, K.C.McKenna and S.L.Gaffen. Th17 cells confer long term adaptive immunity to oral mucosal Candida albicans infections. Mucosal Immunology. 2013. 6, 900-910.

S.R. Slight, L.Monin, R.Gopal, L.Avery, M.Davis, H.Cleveland, Tim.D. Oury, J.Rangel-Moreno, S.A.Khader*. Short Communication: Interleukin-10 restrains Interleukin-17 to limit lung pathology following pulmonary infection with Francisella tularensis LVS. American Journal of Pathology. 2013 Nov;183(5):1397-404.

R.Gopal, L.Monin, D.Torres, S.Slight, S.Mehra, K.McKenna, B.A.Fallert Junecko, T.A.Reinhart, J.Kolls, R.Báez-Saldaña, A.Cruz-Lagunas, T.S.Rodríguez-Reyna, N.P.Kumar, P.Tessier, J.Roth, M.Selman, E.Becerril-Villanueva, J.Baquera-Heredia, B.Cumming, V.O.Kasprowicz, A.JC. Steyne, S. Babu, D.Kaushal, J.Zúñiga, T.Vogl, J.Rangel-Moreno and S.A. Khader*. S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis. The American Journal of Respiratory and Critical Care Medicine. Am J Respir Crit Care Med. 2013 Nov 1;188(9):1137-46.

D.Torres-García, A.Cruz-Lagunas, M.C.García-Sancho, R.Fernández-Plata, R.Baez-Saldaña, C.Mendoza-Milla, A.Carrera-Eusebio, S.Ramírez-Bravo5, L.Campos, J.Angeles, G.Vargas-Alarcón, J.Granados, R.Gopal, S.A.Khader, E.J.Yunis, J.Zuñiga. Variants in toll-like receptor 9 gene influence susceptibility to tuberculosis in a Mexican population. Journal of Translational Medicine. J Transl Med. 2013 Sep 21;11(1):220. [Epub ahead of print].

L.M.Monin and S.A.Khader*. Editorial: B cells produce CXCL13 in lymphoid neogenesis during COPD: the new kid on the block? American Journal of Respiratory and Critical Care Medicine. 2013. Jun1 :187(11):1162-1164.

R.Gopal and S.A.Khader*. Editorial: Vaccines against tuberculosis: Moving forward with new concepts. Expert reviews in Vaccines. 2013. (doi: 10.1586/14760584.2013.814836). Aug 24 online.



R.Gopal, Y.Lin, S.Slight, N.Nuthalapati, N.Obermajer, M.Ahmed, W.Ouyang, P.Kalinski and S.A Khader*. Interleukin-23 dependent IL-17 drives Th1 responses following Mycobacterium bovis BCG vaccination. European Journal of Immunology. 2012. Feb 42(2):364-373. A commentary highlighting the paper was published in the “In this issue” segment of the journal.

L.Guglani, R.Gopal, J. Rangel-Moreno, B.Junecko, Y.Lin, E.V.Scheller, J.Alcorn, T.Berger, T.W.Mak, T.Randall, T.Reinhart, Y.Chan, and S.A.Khader*. Lipocalin 2 regulates inflammation during mycobacterial pulmonary infection. PLoS One. 2012;7(11):e50052. doi: 10.1371/journal.pone.0050052. Epub 2012 Nov 20.

J.Rangel-Moreno, D.M. Carragher, M. Garcia-Hernandez, J.Y.Hwang, K.Kusser, L.Hartson, J.K.Kolls, S.A.Khader and T.D.Randall. Induction of BALT in the absence of IL-17. Nature Immunology. Correspondence. Nature Immunology.2012. 13, 2.doi:10.1038/ni.2168.

S.A.Khader*. Restraining IL-17: Del1 deals the blow. News and views, Nature Immunology, 2012 Apr 18;13(5):433-5. doi: 10.1038/ni.2290.

Samantha R. Slight and S. A. Khader*. Chemokines shape the immune responses to tuberculosis. Cytokine Growth Factor Rev. 2012 Nov 15. doi:pii: S1359-6101(12)00079-2. 10.1016/j.cytogfr.2012.10.002.



A.Kudva, E.V.Scheller, K.M.Robinson, C.R.Crowe, S.R.Slight, S.A.Khader, P.J.Dubin, R.I.Enelow, J.K.Kolls, J.F. Alcorn. Influenza A inhibits Th17 mediated host defense against Bacterial Pneumonia. J. Immunol. 2011 Feb 1;186(3):1666-74.

D. Kang, Y. Lin, J. Rangel-Moreno, T. Randall, S.A.Khader*. Profiling early immune responses in the lung during murine tuberculosis. Plos ONE. Jan 13;6(1):e16161.

Rangel-Moreno, D.Carragher, J.Hwang, M.Luz Garcia-Hernandez, K.Kusser, L.Hartson, W.Ouyang, J.Kolls, S.A. Khader, T.D. Randall. The development of inducible Bronchus Associated Lymphoid Tissue (iBALT) is dependent on IL-17. Nature Immunology. 2011, 639-646.

A special commentary highlighting the finding was published in News and Views of the same issue of Nature Immunology entitled “An unexpected role for IL-17 in lymphoid organogenesis” by T. Cupedo (Nature Immunology, 2011.12: 590-592).

S.R. Slight, Y.Lin, M.Messmer, and S.A. Khader*. Francisella tularensis LVS induces Interleukin-12 p40 cytokines in dendritic cells and mediates Dendritic cell migration and T cell polarization.2011. Cytokine. 55 (2011) 372–379.

S.A.Khader, L.Guglani, J.Rangel-Moreno, J.J Fountain, C.Martino, J. E.Pearl, Y. Lin, W.Ouyang, T.Randall and A.M.Cooper*. IL-23 is required for long-term containment of Mycobacterium tuberculosis growth in the lung. J.Immunol. 2011. Nov 15;187(10):5402-7.

J. Kolls and S.A.Khader. Th17 cells in health and disease. Edited by Shuiping Jiang. Springer New York. 2011. Book Chapter.



R.Robinson, S.A.Khader, C.A.Martino, J.J. Fountain, M.Teixeira-Coelho, JE.Pearl, J.R. Conejo- Garcia, S.T.Smiley, G.M.Winslow, D.L. Woodland, M.J.Walter, U.Gubler, A.M.Cooper. M.tuberculosis infection induces il12rb1 splicing to generate a novel IL12RB1 isoform that enhances DC migration. J. Exp. Med. 2010 207: 591-605.

R.R. Rapaka, D.Ricks, J.F.Alcorn, K.Chen, S.A. Khader, M. Zheng, S.Plevy, E.Bengtén, and J. K. Kolls. Conserved natural IgM antibodies mediate innate and adaptive immunity against the opportunistic fungus Pneumocystis. J.Exp.Med. 2010. 207:2907-19.

Y.Lin, S.Slight and S.A.Khader *. Role of IL-17 in vaccine-induced immunity. Seminars in Immunopathology. 2010 Mar;32(1):79-90.

L.Guglani and S.A.Khader*. IL-17 in mucosal immunity and inflammation. Current Opinion in HIV and AIDS. 2010 Mar 5(2):120-127.

S.A.Khader* and R. Gopal. Interleukin-17 in immunity to intracellular pathogens. Virulence. 2010. Sep-Oct;1(5):423-7.

S.A.Khader*. Editorial. Th17 cytokines; The good, the bad and the unknown. Cytokine Growth reviews. 2010 Dec;21(6):403-4.

J.K. Kolls and S.A.Khader. The role of IL-17 in primary mucosal immunity. Cytokine Growth Reviews. . 2010 Dec;21(6):443-8.



S.A.Khader*, J.Rangel-Moreno, J.J.Fountain, C.Martino, W.Reiley, J.E.Pearl, G.Winslow, D.L.Woodland, T.D.Randall and A.M. Cooper. Pulmonary expression of homeostatic chemokines is essential for protective immunity to Mycobacterium tuberculosis infection. J.Immunol. 2009. Dec 15;183(12):8004-14.

Y.Lin, S.Ritchea, A.Logar, S.Slight, M.Messmer, J.Rangel-Moreno, L.Gulgani, J.Alcorn, H.Strawbridge, S.M. Park, R.Onishi, N.Nyugen, M.Walters, D. Pociask, T.Randall, S.L. Gaffen, Y.Iwakura, J.Kolls and S.A.Khader. IL-17 is required for Th1 immunity and host resistance to the intracellular pathogen Francisella tularensis LVS. Immunity. 2009 Nov 20;31(5):799-810. - A commentary article highlighting these findings was published in the same issue “Interleukin-17 Kick-Starts T Helper 1 Cell Differentiation” (Immunity, Nov 20;31;700-702).

S.A.Khader and J.Kolls. IL-17 in mucosal host defense in Th17 Cells: Role in Inflammation and Autoimmune Disease”. Edited by Quesniaux, Valerie; Ryffel, Bernhard; Di Padova, Franco. 2009. Book Chapter.

S.A.Khader, Sarah Gaffen and Jay Kolls. Th17 cells at the cross roads of innate and adaptive immunity against infectious diseases at the mucosa. Mucosal Immunology. 2009. Online. 8 July 2009. doi:10.1038/mi.2009.100.



R.T.Robinson, S.A. Khader, R.M.Locksley, E. Lien, S.T.Smiley, and A.M.Cooper. Yersinia pestis evades TLR4-dependent induction of IL12(p40)2 by dendritic cells and subsequent cell migration. J Immunol. 2008 Oct 15;181(8):5560-7.

S.A.Khader and A.M. Cooper. IL-23 and IL-17 in tuberculosis. Cytokine . 2008 Feb: 41(2): 79-83.
- Received the honor of “Top Cited Article 2006-2010” given by the journal in 2011.

A.M.Cooper and S.A.Khader . The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis. Immunological Reviews 2008. Vol. 226: 191–204.



S.A.Khader, G.Bell. J.E.Pearl, J.J. Fountain, J-M.Moreno, G.E.Ciley, F. Shen, S.M.Eaton, S.L.Gaffen, S.S.Swain, R.M.Locksley, T.Randall, L.Haynes and A.M.Cooper. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nature Immunology, Apr;8(4):369-77.

A.M.Cooper and S.A.Khader. IL-12p40, an inherently agonistic cytokine. Trends in Immunology. 2007. Jan 28(1): 33-8.

A.M.Cooper, A.Solache and S.A.Khader. Interleukin-12 and tuberculosis: an old story revisited. Current Opinions in Immunology. August 2007.Volume 19, Issue 4: 441-447