2021

Lung Epithelial Signaling Mediates Early Vaccine-Induced CD4 + T Cell Activation and Mycobacterium tuberculosis Control Das S, Marin ND, Esaulova E, Ahmed M, Swain A, Rosa BA, Mitreva M, Rangel-Moreno J, Netea MG, Barreiro LB, Divangahi M, Artyomov MN, Kaushal D, Khader SA. Lung Epithelial Signaling Mediates Early Vaccine-Induced CD4+ T Cell Activation and Mycobacterium tuberculosis Control. mBio. 2021 Jul 13:e0146821. doi: 10.1128/mBio.01468-21. Epub ahead of print. PMID: 34253059.

Phenotype of Peripheral NK Cells in Latent, Active, and Meningeal Tuberculosis Choreño-Parra JA, Jiménez-Álvarez LA, Maldonado-Díaz ED, Cárdenas G, Fernández-Lopez LA, Soto-Hernandez JL, Muñoz-Torrico M, Ramírez-Martínez G, Cruz-Lagunas A, Vega-López A, Domínguez-López ML, Sánchez-Garibay C, Guadarrama-Ortíz P, Giono S, Jiménez-Zamudio LA, Khader SA, García-Latorre EA, Salinas-Lara C, Zúñiga J. Phenotype of Peripheral NK Cells in Latent, Active, and Meningeal Tuberculosis. J Immunol Res. 2021 Apr 27;2021:5517856. doi: 10.1155/2021/5517856. PMID: 34007850; PMCID: PMC8100419.

Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics Chumakov K, Avidan MS, Benn CS, Bertozzi SM, Blatt L, Chang AY, Jamison DT, Khader SA, Kottilil S, Netea MG, Sparrow A, Gallo RC. Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2101718118. doi: 10.1073/pnas.2101718118. PMID: 34006644; PMCID: PMC8166166.

Clinical and Immunological Factors That Distinguish COVID-19 From Pandemic Influenza A(H1N1) Choreño-Parra JA, Jiménez-Álvarez LA, Cruz-Lagunas A, Rodríguez-Reyna TS, Ramírez-Martínez G, Sandoval-Vega M, Hernández-García DL, Choreño-Parra EM, Balderas-Martínez YI, Martinez-Sánchez ME, Márquez-García E, Sciutto E, Moreno-Rodríguez J, Barreto-Rodríguez JO, Vázquez-Rojas H, Centeno-Sáenz GI, Alvarado-Peña N, Salinas-Lara C, Sánchez-Garibay C, Galeana-Cadena D, Hernández G, Mendoza-Milla C, Domínguez A, Granados J, Mena-Hernández L, Pérez-Buenfil LÁ, Domínguez-Cheritt G, Cabello-Gutiérrez C, Luna-Rivero C, Salas-Hernández J, Santillán-Doherty P, Regalado J, Hernández-Martínez A, Orozco L, Ávila-Moreno F, García-Latorre EA, Hernández-Cárdenas CM, Khader SA, Zlotnik A, Zúñiga J. Clinical and Immunological Factors That Distinguish COVID-19 From Pandemic Influenza A(H1N1). Front Immunol. 2021 Apr 21;12:593595. doi: 10.3389/fimmu.2021.593595. PMID: 33995342; PMCID: PMC8115405.

Monocyte progenitors give rise to multinucleated giant cells Lösslein AK, Lohrmann F, Scheuermann L, Gharun K, Neuber J, Kolter J, Forde AJ, Kleimeyer C, Poh YY, Mack M, Triantafyllopoulou A, Dunlap MD, Khader SA, Seidl M, Hölscher A, Hölscher C, Guan XL, Dorhoi A, Henneke P. Nat Commun. 2021 Apr 1;12(1):2027. doi: 10.1038/s41467-021-22103-5. PMID: 33795674; PMCID: PMC8016882.

IFN signaling and neutrophil degranulation transcriptional signatures are induced durings SARS-CoV-2 infection Rosa BA, Ahmed M, Singh DK, Choreño-Parra JA, Cole J, Jiménez-Álvarez LA, Rodríguez-Reyna TS, Singh B, Gonzalez O, Carrion R Jr, Schlesinger LS, Martin J, Zúñiga J, Mitreva M, Kaushal D, Khader SA. Commun Biol. 2021 Mar 5;4(1):290. doi: 10.1038/s42003-021-01829-4. PMID: 33674719; PMCID: PMC7935909.

Expression of Surfactant protein D (SP-D) distinguishes severe pandemic influenza A(H1N1) from COVID-19 Choreño-Parra JA, Jiménez-Álvarez LA, Ramírez-Martínez G, Cruz-Lagunas A, Thapa M, Fernández-López LA, Carnalla-Cortés M, Choreño-Parra EM, Mena-Hernández L, Sandoval-Vega M, Hernández-Montiel EM, Hernández-García DL, Ramírez-Noyola JA, Reyes-López CE, Domínguez-Faure A, Zamudio-López GY, Márquez-García E, Moncada-Morales A, Mendoza-Milla C, Cervántes-Rosete D, Muñoz-Torrico M, Luna-Rivero C, García-Latorre EA, Guadarrama-Ortíz P, Ávila-Moreno F, Domínguez-Cherit G, Rodríguez-Reyna TS, Mudd PA, Hernández-Cárdenas CM, Khader SA, Zúñiga J. J Infect Dis. 2021 Mar 1:jiab113. doi: 10.1093/infdis/jiab113. Epub ahead of print. PMID: 33668070; PMCID: PMC7989215.

CXCL17 is a Specific Diagnostic Biomarker for Severe Pandemic Influenza A(H1N1) That Predicts Poor Clinical Outcome Choreño-Parra JA, Jiménez-Álvarez LA, Ramírez-Martínez G, Sandoval-Vega M, Salinas-Lara C, Sánchez-Garibay C, Luna-Rivero C, Hernández-Montiel EM, Fernández-López LA, Cabrera-Cornejo MF, Choreño-Parra EM, Cruz-Lagunas A, Domínguez A, Márquez-García E, Cabello-Gutiérrez C, Bolaños-Morales FV, Mena-Hernández L, Delgado-Zaldivar D, Rebolledo-García D, Guadarrama-Ortiz P, Regino-Zamarripa NE, Mendoza-Milla C, García-Latorre EA, Rodiguez-Reyna TS, Cervántes-Rosete D, Hernández-Cárdenas CM, Khader SA, Zlotnik A, Zúñiga J. Front Immunol. 2021 Feb 26;12:633297. doi: 10.3389/fimmu.2021.633297. PMID: 33717172; PMCID: PMC7953906.

Trained immunity, tolerance, priming and differentiation: distinct immunological processes Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenwoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O’Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG. Nat Immunol. 2021 Jan;22(1):2-6. doi: 10.1038/s41590-020-00845-6. PMID: 33293712.

2020

Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets Singh DK, Singh B, Ganatra SR, Gazi M, Cole J, Thippeshappa R, Alfson KJ, Clemmons E, Gonzalez O, Escobedo R, Lee TH, Chatterjee A, Goez-Gazi Y, Sharan R, Gough M, Alvarez C, Blakley A, Ferdin J, Bartley C, Staples H, Parodi L, Callery J, Mannino A, Klaffke B, Escareno P, Platt RN 2nd, Hodara V, Scordo J, Gautam S, Vilanova AG, Olmo-Fontanez A, Schami A, Oyejide A, Ajithdoss DK, Copin R, Baum A, Kyratsous C, Alvarez X, Ahmed M, Rosa B, Goodroe A, Dutton J, Hall-Ursone S, Frost PA, Voges AK, Ross CN, Sayers K, Chen C, Hallam C, Khader SA, Mitreva M, Anderson TJC, Martinez-Sobrido L, Patterson JL, Turner J, Torrelles JB, Dick EJ Jr, Brasky K, Schlesinger LS, Giavedoni LD, Carrion R Jr, Kaushal D. Nat Microbiol. 2021 Jan;6(1):73-86. doi: 10.1038/s41564-020-00841-4. Epub 2020 Dec 18. PMID: 33340034.

The immune landscape in tuberculosis reveals populations linked to disease and latency E, Das S, Singh DK, Choreño-Parra JA, Swain A, Arthur L, Rangel-Moreno J, Ahmed M, Singh B, Gupta A, Fernández-López LA, de la Luz Garcia-Hernandez M, Bucsan A, Moodley C, Mehra S, García-Latorre E, Zuniga J, Atkinson J, Kaushal D, Artyomov MN, Khader SA. Cell Host Microbe. 2020 Dec 16:S1931-3128(20)30635-1. doi: 10.1016/j.chom.2020.11.013. Epub ahead of print. PMID: 33340449.

Antiretroviral therapy does not reduce tuberculosis reactivation in a tuberculosis-HIV coinfection model
Ganatra SR, Bucsan AN, Alvarez X, Kumar S, Chatterjee A, Quezada M, et al. The Journal of clinical investigation. 2020.

Targeting unconventional host components for vaccination-induced protection against TB Elisa Nemes, Shabaana A Khader, Rosemary V Swanson, Willem A Hanekom. Frontiers in Immunology, section Vaccines and Molecular Therapeutics

Formation of lung inducible Bronchus Associated Lymphoid Tissue is regulated by Mycobacterium tuberculosis expressed 
Micah Dunlap, Oliver A Prince, Javier Rangel-Moreno, Kimberly Thomas, Julia Scordo, Jordi B Torrelles, Jeffery Cox, Adrie JC Steyn, Joaquín Zúñiga, Deepak Kaushal, Shabaana Khader
Frontiers in Immunology, section Microbial Immunology

The protective and pathogenic roles of CXCL17 in human health and disease: potential in respiratory medicine   
Choreño-Parra JA, Thirunavukkarasu S, Zúñiga J, Khader SA.Cytokine Growth Factor Rev. 2020 Apr 23:S1359-6101(20)30044-7. doi: 10.1016/j.cytogfr.2020.04.004. Online ahead of print. PMID: 32345516 

Therapies for tuberculosis and AIDS: myeloid-derived suppressor cells in focus
Dorhoi A, Kotzé LA, Berzofsky JA, Sui Y, Gabrilovich DI, Garg A, Hafner R, Khader SA, Schaible UE, Kaufmann SH, Walzl G, Lutz MB, Mahon RN, Ostrand-Rosenberg S, Bishai W, du Plessis N.J Clin Invest. 2020 Jun 1;130(6):2789-2799. doi: 10.1172/JCI136288.PMID: 32420917 

Immunometabolism during Mycobacterium tuberculosis infection
Howard NC, Khader SA Trends Microbiol. 2020 May 11:S0966-842X(20)30103-7. doi: 10.1016/j.tim.2020.04.010. Online ahead of print.PMID: 32409147

Cryptococcus neoformans evades pulmonary immunity by modulating xylose precursor transport
Li LX, Hole CR, Rangel-Moreno J, Khader SA, Doering TL.Infect Immun. 2020 May 18:IAI.00288-20. doi: 10.1128/IAI.00288-20. Online ahead of print.PMID: 32423915

Immune correlates of tuberculosis disease and risk translate across species.
Ahmed M, Thirunavukkarasu S, Rosa BA, Thomas KA, Das S, Rangel-Moreno J, Lu L, Mehra S, Mbandi SK, Thackray LB, Diamond MS, Murphy KM, Means T, Martin J, Kaushal D, Scriba TJ, Mitreva M, Khader SA. Sci Transl Med. 2020 Jan 29;12(528). pii: eaay0233. doi: 10.1126/scitranslmed.aay0233.PMID: 31996462

2019


Mycobacterium tuberculosis HN878 infection induces human-like B cell follicles in mice.
Alberto Choreño-Parra J,Bobba S, Rangel-Moreno J, Ahmed M, Mehra S, Rosa B, Martin J, Mitreva M, Kaushal D, Zúñiga J, Khader SA. J Infect Dis. 2019 Dec 13. pii: jiz663. doi: 10.1093/infdis/jiz663.PMID: 31832640

Mechanisms of reactivation of latent tuberculosis infection due to SIV coinfection.
Bucşan AN, Chatterjee A, Singh DK, Foreman TW, Lee TH, Threeton B, Kirkpatrick MG, Ahmed M, Golden N, Alvarez X, Hoxie JA, Mehra S, Rengarajan J, Khader SA, Kaushal D. J Clin Invest. 2019 Oct 28. pii: 125810. doi: 10.1172/JCI125810.PMID: 31479428

Targeting innate immunity for tuberculosis vaccination.
Khader SA, Divangahi M, Hanekom W, Hill PC, Maeurer M, Makar KW, Mayer-Barber KD, Mhlanga MM, Nemes E, Schlesinger LS, van Crevel R, Vankalayapati R, Xavier RJ, Netea MG; Bill and Melinda Gates Foundation Collaboration for TB Vaccine Discovery Innate Immunity Working Group18. J Clin Invest. 2019 Sep 3;129(9):3482-3491. doi: 10.1172/JCI128877. Review.PMID: 31478909

The current state of animal models and genomic approaches towards identifying and validating molecular determinants of Mycobacterium tuberculosis infection and tuberculosis disease.
Bucsan AN, Mehra S, Khader SA, Kaushal D. Pathog Dis. 2019 Jun 1;77(4). pii: ftz037. doi: 10.1093/femspd/ftz037.PMID: 31381766

Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis.
Ardain A, Domingo-Gonzalez R, Das S, Kazer SW, Howard NC, Singh A, Ahmed M, Nhamoyebonde S, Rangel-Moreno J, Ogongo P, Lu L, Ramsuran D, de la Luz Garcia-Hernandez M, K Ulland T, Darby M, Park E, Karim F, Melocchi L, Madansein R, Dullabh KJ, Dunlap M, Marin-Agudelo N, Ebihara T, Ndung’u T, Kaushal D, Pym AS, Kolls JK, Steyn A, Zúñiga J, Horsnell W, Yokoyama WM, Shalek AK, Kløverpris HN, Colonna M, Leslie A, Khader SA. Nature. 2019 Jun;570(7762):528-532. doi: 10.1038/s41586-019-1276-2. Epub 2019 Jun 5. Erratum in: Nature. 2019 Jul 24.PMID: 31168092

Mucosal-activated invariant T cells do not exhibit significant lung recruitment and proliferation profiles in macaques in response to infection with Mycobacterium tuberculosis CDC1551.
Bucsan AN, Rout N, Foreman TW, Khader SA, Rengarajan J, Kaushal D. Tuberculosis (Edinb). 2019 May;116S:S11-S18. doi: 10.1016/j.tube.2019.04.006. Epub 2019 Apr 26.PMID: 31072689

Advances in Cardiovascular Disease Lipid Research Can Provide Novel Insights Into Mycobacterial Pathogenesis.
Thirunavukkarasu S, Khader SA. Front Cell Infect Microbiol. 2019 Apr 18;9:116. doi: 10.3389/fcimb.2019.00116. eCollection 2019. Review.PMID: 31058102

Friend or Foe: The Protective and Pathological Roles of Inducible Bronchus-Associated Lymphoid Tissue in Pulmonary Diseases.
Marin ND, Dunlap MD, Kaushal D, Khader SA. J Immunol. 2019 May 1;202(9):2519-2526. doi: 10.4049/jimmunol.1801135. Review.PMID: 31010841

HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis.
Corleis B, Bucsan AN, Deruaz M, Vrbanac VD, Lisanti-Park AC, Gates SJ, Linder AH, Paer JM, Olson GS, Bowman BA, Schiff AE, Medoff BD, Tager AM, Luster AD, Khader SA, Kaushal D, Kwon DS. Cell Rep. 2019 Feb 5;26(6):1409-1418.e5. doi: 10.1016/j.celrep.2019.01.021.PMID: 30726727

The Tale of IL-12 and IL-23: A Paradigm Shift.
Khader SA, Thirunavukkarasu S. J Immunol. 2019 Feb 1;202(3):629-630. doi: 10.4049/jimmunol.1801603. No abstract available.PMID: 30670577

2018


Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes.
Howard NC, Marin ND, Ahmed M, Rosa BA, Martin J, Bambouskova M, Sergushichev A, Loginicheva E, Kurepina N, Rangel-Moreno J, Chen L, Kreiswirth BN, Klein RS, Balada-Llasat JM, Torrelles JB, Amarasinghe GK, Mitreva M, Artyomov MN, Hsu FF, Mathema B, Khader SA. Nat Microbiol. 2018 Oct;3(10):1099-1108. doi: 10.1038/s41564-018-0245-0. Epub 2018 Sep 17. Erratum in: Nat Microbiol. 2018 Nov;3(11):1327.PMID: 30224802

A novel role for C-C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis.
Dunlap MD, Howard N, Das S, Scott N, Ahmed M, Prince O, Rangel-Moreno J, Rosa BA, Martin J, Kaushal D, Kaplan G, Mitreva M, Kim KW, Randolph GJ, Khader SA. Mucosal Immunol. 2018 Nov;11(6):1727-1742. doi: 10.1038/s41385-018-0071-y. Epub 2018 Aug 16.PMID: 30115997

Aspergillus fumigatus Preexposure Worsens Pathology and Improves Control of Mycobacterium abscessus Pulmonary Infection in Mice.
Monin L, Mehta S, Elsegeiny W, Gopal R, McAleer JP, Oury TD, Kolls J, Khader SA. Infect Immun. 2018 Feb 20;86(3). pii: e00859-17. doi: 10.1128/IAI.00859-17. Print 2018 Mar.PMID: 29263106

In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis.
Gautam US, Foreman TW, Bucsan AN, Veatch AV, Alvarez X, Adekambi T, Golden NA, Gentry KM, Doyle-Meyers LA, Russell-Lodrigue KE, Didier PJ, Blanchard JL, Kousoulas KG, Lackner AA, Kalman D, Rengarajan J, Khader SA, Kaushal D, Mehra S. Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):E62-E71. doi: 10.1073/pnas.1711373114. Epub 2017 Dec 18.PMID: 29255022

2017


Interleukin-17 limits hypoxia-inducible factor 1α and development of hypoxic granulomas during tuberculosis.
Domingo-Gonzalez R, Das S, Griffiths KL, Ahmed M, Bambouskova M, Gopal R, Gondi S, Muñoz-Torrico M, Salazar-Lezama MA, Cruz-Lagunas A, Jiménez-Álvarez L, Ramirez-Martinez G, Espinosa-Soto R, Sultana T, Lyons-Weiler J, Reinhart TA, Arcos J, de la Luz Garcia-Hernandez M, Mastrangelo MA, Al-Hammadi N, Townsend R, Balada-Llasat JM, Torrelles JB, Kaplan G, Horne W, Kolls JK, Artyomov MN, Rangel-Moreno J, Zúñiga J, Khader SA. JCI Insight. 2017 Oct 5;2(19). pii: 92973. doi: 10.1172/jci.insight.92973.PMID: 28978810

RNA Interference Screening Reveals Host CaMK4 as a Regulator of Cryptococcal Uptake and Pathogenesis.
Srikanta D, Hole CR, Williams M, Khader SA, Doering TL. Infect Immun. 2017 Nov 17;85(12). pii: e00195-17. doi: 10.1128/IAI.00195-17. Print 2017 Dec.PMID: 28970273

Nonpathologic Infection of Macaques by an Attenuated Mycobacterial Vaccine Is Not Reactivated in the Setting of HIV Co-Infection.
Foreman TW, Veatch AV, LoBato DN, Didier PJ, Doyle-Meyers LA, Russell-Lodrigue KE, Lackner AA, Kousoulas KG, Khader SA, Kaushal D, Mehra S. Am J Pathol. 2017 Dec;187(12):2811-2820. doi: 10.1016/j.ajpath.2017.08.014. Epub 2017 Sep 19.PMID: 28935575

Dancing with the Stars: Phenolic Glycolipids Partners with Macrophages.
Dunlap MD, Khader SA. Cell Host Microbe. 2017 Sep 13;22(3):249-251. doi: 10.1016/j.chom.2017.08.016.PMID: 28910627

A novel nanoemulsion vaccine induces mucosal Interleukin-17 responses and confers protection upon Mycobacterium tuberculosis challenge in mice.
Ahmed M, Smith DM, Hamouda T, Rangel-Moreno J, Fattom A, Khader SA. Vaccine. 2017 Sep 5;35(37):4983-4989. doi: 10.1016/j.vaccine.2017.07.073. Epub 2017 Jul 31.PMID: 28774560

Yin and yang of interleukin-17 in host immunity to infection.
Das S, Khader S. F1000Res. 2017 May 23;6:741. doi: 10.12688/f1000research.10862.1. eCollection 2017. Review.PMID: 28713557

A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression.
García-Hernández ML, Uribe-Uribe NO, Espinosa-González R, Kast WM, Khader SA, Rangel-Moreno J. Front Immunol. 2017 May 17;8:563. doi: 10.3389/fimmu.2017.00563. eCollection 2017.PMID: 28567040

Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity.
Eddens T, Elsegeiny W, Garcia-Hernadez ML, Castillo P, Trevejo-Nunez G, Serody K, Campfield BT, Khader SA, Chen K, Rangel-Moreno J, Kolls JK. Cell Rep. 2017 Mar 28;18(13):3078-3090. doi: 10.1016/j.celrep.2017.03.016.PMID: 28355561

Rationalized design of a mucosal vaccine protects against Mycobacterium tuberculosis challenge in mice.
Ahmed M, Jiao H, Domingo-Gonzalez R, Das S, Griffiths KL, Rangel-Moreno J, Nagarajan UM, Khader SA. J Leukoc Biol. 2017 Jun;101(6):1373-1381. doi: 10.1189/jlb.4A0616-270R. Epub 2017 Mar 3.PMID: 28258153

2016


Cytokines and Chemokines in Mycobacterium tuberculosis Infection.
Racquel Domingo-Gonzalez, Oliver Prince, Andrea Cooper, and SA. Khader. Microbiol Spectr. 2016 Oct;4(5). doi: 10.1128/microbiolspec.TBTB2-0018-2016 PMID: 27763255

Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy.
Kristin L. Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D. Connell,Kelly D. Moynihan, Jay K. Kolls, Darrell J. Irvine, Maxim N. Artyomov, Javier Rangel-Moreno & Shabaana A. Khader. Published 22 Dec 2016 doi: 10.1038/ncomms13894.PMID: 28004802

Computational analysis reveals a key regulator of cryptococcal virulence and determinant of host response.
S.R. Gish, E.J.Maier, B.C.Haynes, F.H.Santiago-Tirado, D.L. Srikanta, C.Z. Ma, L.X. Li, M.Williams, E.C. Crouch, S.A. Khader, M.R. Brent, and T. L. Doering. mBio, 2016 Apr 19;7(2). pii: e00313-16. doi: 10.1128/mBio.00313-16.PMID: 27094327

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
V.Lampropoulou, A.Sergushichev, M.Bambouskova, S.Nair, E.Vincent, E.Loginicheva, L.Cervantes-Barragan, X.Ma, S.Ching-Cheng Huang, C.J. Weinheimer, S.Khader, G.J. Randolph, E.J.Pearce, R.G.Jones, A.Diwan, M.S. Diamond, M.N. Artyomov. Cell Metabolism, 2016 Jul 12;24(1):158-66. doi: 10.1016/j.cmet.2016.06.004.PMID: 27374498

A novel multivalent tuberculosis vaccine confers protection in a mouse model of tuberculosis.
K.L.Griffiths, D.O.Villarreal, D.B. Weiner, S.A. Khader. Hum Vaccin Immunother. 2016 Oct 2;12(10):2649-2653. doi: 10.1080/21645515.2016.1197454.PMID: 27322875

2015


Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge.
L.Monin, K.Griffiths, S.Slight, Y.Lin, J.Rangel-Moreno, S.A. Khader. Mucosal Immunol. 2015 Jan 28. doi: 10.1038/mi.2014.136.PMID: 25627812

The DosR regulon modulates adaptive immunity and is essential for M. tuberculosis persistence.
S.Mehra, T.W. Foreman, P.J. Didier, M.H. Ahsan, T.A. Hudock, R.Kissee2, N.A.Golden, U.S. Gautam, X.Alvarez, K.E.Russell-Lodrigue, L.A. Doyle, C.J.Roy, J.L.Blanchard, S.A.Khader, A,A.Lackner, D.R.Sherman, D.Kaushal. Am J Respir Crit Care Med. 2015 May 15;191(10):1185-96. doi: 10.1164/rccm.201408-1502OC.PMID: 25730547

Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis.
L.Monin, KL.Griffiths, WY.Lam, R.Gopal, DD.Kang, M.Ahmed, A.Rajamanickam, A.Cruz-Lagunas, J. Zúñiga, S. Babu, JK.Kolls, M.Mitreva, B.A.Rosa, R.Ramos-Payan, T.E. Morrison, PJ. Murray, J. Rangel-Moreno, EJ. Pearce and S.A.Khader. J Clin Invest. 2015 Nov 16. pii: 77378. doi: 10.1172/JCI77378.PMID: 26571397

Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects macaques against lethal tuberculosis.
D.Kaushal, T.W. Foreman, T.Adekambi, U.S.Gautam, J.Rangel-Moreno, N. A. Golden, A.F. Johnson, B.L.Phillips, K.E.Russell-Lodrigue, L.A.Doyle, P.J. Didier, J.L. Blanchard, J.Rengarajan, A.A.Lackner, S.A.Khader, S.Mehra. Nat Commun. 2015 Oct 13;6:8533. doi: 10.1038/ncomms9533.PMID: 26460802

2014


LAG-expression in active Mycobacterium tuberculosis infections.
B.L.Phillips, S.Mehra, M.H.Ahsan, M.Selman, S.A.Khader, D.Kaushal. American Journal of Pathology, 2014 Dec 27. pii: S0002-9440(14)00671-3. doi: 10.1016/j.ajpath.2014.11.003.PMID: 25549835

Editorial overview: Vaccines for infectious diseases: Are we there yet?
S.A.Khader and J.K.Kolls. Curr Opin Immunol. 2014 Jun;28:ix-x. doi:10.1016/j.coi.2014.03.005. PMID: 24735901

Chemokines in tuberculosis: The Good, the bad and the ugly.
L.Monin and S.A.Khader. Seminars in Immunopathology. 2014 Dec;26(6):552-8. doi: 10.1016/j.smim.2014.09.004.PMID: 25444549

Bringing in the cavalry: IL-26 mediates neutrophil recruitment to the lungs.
K.Griffiths and S.A.Khader. American Journal of Respiratory and Critical Care Medicine. Am J Respir Crit Care Med. 2014 Nov 15;190(10):1079-80. doi: 10.1164/rccm.201410-1870ED. PMID: 25398102

Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection.
R.Gopal, L.Monin, S.Slight, U.Uche, E.Blanchard, B.Fallert Junecko, R. Ramos-Payan, C.L.Stallings, T.A.Reinhart, J.K.Kolls, D.Kaushal, U.Nagarajan, J.Rangel-Moreno and S.A. Khader. PLoS Pathog. 2014 May 15;10(5):e1004099. doi: 10.1371/journal.ppat.1004099. PMID: 24831696

Novel vaccine approaches for protection against intracellular pathogens.
Kristin Griffiths and S.A.Khader. Curr Opin Immunol. 2014 Jun;28C:58-63. doi: 10.1016/j.coi.2014.02.003.PMID: 24608070

Mucosal pre-exposure to Th17-inducing adjuvants exacerbates pathology following influenza infection.
R.Gopal, J.Rangel-Moreno, B.Fallert Junecko, D.Mallon, K.Chen, D.Pociask, T.D. Connell, T.A.Reinhart, J.F.Alcorn, T.M.Ross, J.K.Kolls, and S.A.Khader. Am J Pathol. 2014 Jan; 184(1): 55–63. doi: 10.1016/j.ajpath.2013.09.012.PMID: 24183780

2013


Interleukin-17-dependent CXCL-13 mediates mucosal vaccine-induced immunity against tuberculosis.
R.Gopal, J.Rangel-Moreno, S.Slight, Y.Lin, H.F.Nawar, B.A. Fallert Junecko, T.A. Reinhart, J.Kolls,T.D. Randall, T.D. Connell and S.A. Khader. Mucosal Immunol. 2013 September ; 6(5): 972–984. doi:10.1038/mi.2012.135.PMID: 23299616

CXCR5+ T helper cells mediate protective immunity against tuberculosis.
Slight SR, Rangel-Moreno J, Gopal R, Lin Y, Fallert Junecko BA, Mehra S, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Pavon L, Kaushal D, Reinhart TA, Randall TD, Khader SA. J Clin Invest. 2013 Feb;123(2):712-26. doi: 10.1172/JCI65728.PMID: 23281399

Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling.
N.Obermajer, J.Wong, R.P.Edwards, K.Chen, M.Scott, S.A.Khader, K.Odunsi, T.R.Billiar and P.Kalinski. J Exp Med. 2013 Jul 1; 210(7): 1433–1445. doi: 10.1084/jem.20121277.PMID: 23797095

Th17 cells confer long term adaptive immunity to oral mucosal Candida albicans infections.
N.Hernandez-Santos, A.C. Peterson, A.R. Huppler, S.A. Khader, K.C.McKenna and S.L.Gaffen. Mucosal Immunol. 2013 September; 6(5): 900–910. doi:10.1038/mi.2012.128.PMID: 23250275

Interleukin-10 restrains Interleukin-17 to limit lung pathology following pulmonary infection with Francisella tularensis LVS.
S.R. Slight, L.Monin, R.Gopal, L.Avery, M.Davis, H.Cleveland, Tim.D. Oury, J.Rangel-Moreno, S.A.Khader. Am J Pathol. 2013 Nov; 183(5): 1397–1404. doi: 10.1016/j.ajpath.2013.07.008. PMID:24007881

S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis.
R.Gopal, L.Monin, D.Torres, S.Slight, S.Mehra, K.McKenna, B.A.Fallert Junecko, T.A.Reinhart, J.Kolls, R.Báez-Saldaña, A.Cruz-Lagunas, T.S.Rodríguez-Reyna, N.P.Kumar, P.Tessier, J.Roth, M.Selman, E.Becerril-Villanueva, J.Baquera-Heredia, B.Cumming, V.O.Kasprowicz, A.JC. Steyne, S. Babu, D.Kaushal, J.Zúñiga, T.Vogl, J.Rangel-Moreno and S.A. Khader.

Am J Respir Crit Care Med. 2013 Nov 1; 188(9): 1137–1146. doi: 10.1164/rccm.201304-0803OC.PMID: 24047412

Variants in toll-like receptor 9 gene influence susceptibility to tuberculosis in a Mexican population.
D.Torres-García, A.Cruz-Lagunas, M.C.García-Sancho, R.Fernández-Plata, R.Baez-Saldaña, C.Mendoza-Milla, A.Carrera-Eusebio, S.Ramírez-Bravo5, L.Campos, J.Angeles, G.Vargas-Alarcón, J.Granados, R.Gopal, S.A.Khader, E.J.Yunis, J.Zuñiga. J Transl Med. 2013; 11: 220. Published online 2013 Sep 21. doi: 10.1186/1479-5876-11-220.PMID: 24053111

B cells produce CXCL13 in lymphoid neogenesis during COPD: the new kid on the block?
L.M.Monin and S.A.Khader. Am J Respir Crit Care Med. 2013 Jun 1; 187(11): 1162–1164 doi: 10.1164/rccm.201303-0552ED.PMID: 23725611

Vaccines against tuberculosis: Moving forward with new concepts.
R.Gopal and S.A.Khader. Expert Rev Vaccines. 2013 August ; 12(8): 829–831. doi:10.1586/14760584.2013.814836.PMID: 23944644

2012


Interleukin-23 dependent IL-17 drives Th1 responses following Mycobacterium bovis BCG vaccination.
R.Gopal, Y.Lin, S.Slight, N.Nuthalapati, N.Obermajer, M.Ahmed, W.Ouyang, P.Kalinski and S.A Khader.  doi: 10.1002/eji.201141569.PMID: 22101830

Lipocalin 2 regulates inflammation during mycobacterial pulmonary infection.
L.Guglani, R.Gopal, J. Rangel-Moreno, B.Junecko, Y.Lin, E.V.Scheller, J.Alcorn, T.Berger, T.W.Mak, T.Randall, T.Reinhart, Y.Chan, and S.A.Khader. PLoS One. 2012;7(11):e50052. doi: 10.1371/journal.pone.0050052.PMID: 23185529

The Development of Inducible Bronchus-Associated Lymphoid Tissue Depends on IL-17.
J.Rangel-Moreno, D.M. Carragher, M. Garcia-Hernandez, J.Y.Hwang, K.Kusser, L.Hartson, J.K.Kolls, S.A.Khader and T.D.Randall.  doi: 10.1038/ni.2053 PMID: 21666689

Restraining IL-17: Del1 deals the blow.
S.A.Khader. Nature Immunology, 2012 Apr 18;13(5):433-5. doi: 10.1038/ni.2290.PMID: 22513326

Chemokines shape the immune responses to tuberculosis.
Samantha R. Slight and S. A. Khader. Cytokine Growth Factor Rev.2012 Nov 15. DOI: 10.1016/j.cytogfr.2012.10.002.PMID: 23168132

2011


Influenza A inhibits Th17 mediated host defense against Bacterial Pneumonia in Mice.
A.Kudva, E.V.Scheller, K.M.Robinson, C.R.Crowe, S.R.Slight, S.A.Khader, P.J.Dubin, R.I.Enelow, J.K.Kolls, J.F. Alcorn. J. Immunol. 2011 Feb 1;186(3):1666-74. DOI: 10.4049/jimmunol.1002194. PMID: 21178015

Profiling early immune responses in the lung during murine tuberculosis.
D. Kang, Y. Lin, J. Rangel-Moreno, T. Randall, S.A.Khader. Plos ONE. Jan 13;6(1):e16161. DOI: 10.1371/journal.pone.0016161. PMID: 21249199

The development of inducible Bronchus Associated Lymphoid Tissue (iBALT) is dependent on IL-17.
Rangel-Moreno, D.Carragher, J.Hwang, M.Luz Garcia-Hernandez, K.Kusser, L.Hartson, W.Ouyang, J.Kolls, S.A. Khader, T.D. Randall.  doi: 10.1038/ni.2053.PMID: 21666689

Francisella tularensis LVS-induced Interleukin-12 p40 cytokine production mediates Dendritic cell migration through IL-12 Receptor β1.
S.R. Slight, Y.Lin, M.Messmer, and S.A. Khader.  doi: 10.1016/j.cyto.2011.05.017.PMID: 21669537

IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung.
S.A.Khader, L.Guglani, J.Rangel-Moreno, J.J Fountain, C.Martino, J. E.Pearl, Y. Lin, W.Ouyang, T.Randall and A.M.Cooper. J Immunol. 2011 Nov 15; 187(10): 5402–5407. doi: 10.4049/jimmunol.1101377.PMID: 22003199

Th17 cells in health and disease.
J. Kolls and S.A.Khader. Edited by Shuiping Jiang. Springer New York. 2011. Book Chapter.

2010


M.tuberculosis infection induces il12rb1 splicing to generate a novel IL12RB1 isoform that enhances DC migration.
R.Robinson, S.A.Khader, C.A.Martino, J.J. Fountain, M.Teixeira-Coelho, JE.Pearl, J.R. Conejo- Garcia, S.T.Smiley, G.M.Winslow, D.L. Woodland, M.J.Walter, U.Gubler, A.M.Cooper. J Exp Med. 2010 Mar 15; 207(3): 591–605. doi: 10.1084/jem.20091085.PMID: 20212068

Conserved natural IgM antibodies mediate innate and adaptive immunity against the opportunistic fungus Pneumocystis murina.
R.R. Rapaka, D.Ricks, J.F.Alcorn, K.Chen, S.A. Khader, M. Zheng, S.Plevy, E.Bengtén, and J. K. Kolls. J Exp Med. 2010 Dec 20; 207(13): 2907–2919. doi: 10.1084/jem.20100034.PMID: 21149550

Th17 cytokines and Vaccine Induced Immunity
Y.Lin, S.Slight and S.A.Khader .  doi: 10.1007/s00281-009-0191-2.PMID: 20112107

Th17 cytokines in mucosal immunity and inflammation
L.Guglani and S.A.Khader. Curr Opin HIV AIDS. 2010 Mar; 5(2): 120–127. doi: 10.1097/COH.0b013e328335c2f6.PMID: 20543588

IL-17 in protective immunity to intracellular pathogens.
S.A.Khader and R. Gopal. Virulence. 2010 Sep-Oct; 1(5): 423–427. doi: 10.4161/viru.1.5.12862 PMID: 21178483

Editorial. Th17 cytokines; The good, the bad and the unknown.
S.A.Khader. Cytokine Growth Factor Rev. 2010 Dec;21(6):403-4. doi: 10.1016/j.cytogfr.2010.10.008. PMID: 21075041

The role of Th17 cytokines in primary mucosal immunity.
J.K. Kolls and S.A.Khader. Cytokine Growth Factor Rev. 2010 Dec; 21(6): 443–448. doi: 10.1016/j.cytogfr.2010.11.002.PMID: 21095154

2009


In a murine tuberculosis model, the absence of homeostatic chemokines delay granuloma formation and protective immunity.
S.A.Khader, J.Rangel-Moreno, J.J.Fountain, C.Martino, W.Reiley, J.E.Pearl, G.Winslow, D.L.Woodland, T.D.Randall and A.M. Cooper. J Immunol. 2009 Dec 15; 183(12): 8004–8014. doi: 10.4049/jimmunol.0901937.PMID: 19933855

IL-17 is required for Th1 immunity and host resistance to the intracellular pathogen Francisella tularensis LVS.
Y.Lin, S.Ritchea, A.Logar, S.Slight, M.Messmer, J.Rangel-Moreno, L.Gulgani, J.Alcorn, H.Strawbridge, S.M. Park, R.Onishi, N.Nyugen, M.Walters, D. Pociask, T.Randall, S.L. Gaffen, Y.Iwakura, J.Kolls and S.A.Khader. Immunity. 2009 Nov 20; 31(5): 799–810. doi: 10.1016/j.immuni.2009.08.025.PMID: 19853481

IL-17 in mucosal host defense in Th17 Cells: Role in Inflammation and Autoimmune Disease.
S.A.Khader and J.Kolls. Edited by Quesniaux, Valerie; Ryffel, Bernhard; Di Padova, Franco. 2009. Book Chapter.

Th17 cells at the cross roads of innate and adaptive immunity against infectious diseases at the mucosa.
S.A.Khader, Sarah Gaffen and Jay Kolls. Mucosal Immunol. 2009 Sep; 2(5): 403–411. doi: 10.1038/mi.2009.100.PMID: 19587639

2008


Yersinia pestis evades TLR4-dependent induction of IL12(p40)2 by dendritic cells and subsequent cell migration.
R.T.Robinson, S.A. Khader, R.M.Locksley, E. Lien, S.T.Smiley, and A.M.Cooper. J Immunol. 2008 Oct 15; 181(8): 5560–5567. doi: 10.4049/jimmunol.181.8.5560.PMID: 18832714

IL-23 and IL-17 in tuberculosis.
S.A.Khader and A.M. Cooper. Cytokine. 2008 Feb; 41(2): 79–83. doi: 10.1016/j.cyto.2007.11.022.PMID: 18218322

The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis.
A.M.Cooper and S.A.Khader Immunol Rev. 2008 Dec; 226: 191–204. doi: 10.1111/j.1600-065X.2008.00702.x.PMID: 19161425

2007


IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge.
S.A.Khader, G.Bell. J.E.Pearl, J.J. Fountain, J-M.Moreno, G.E.Ciley, F. Shen, S.M.Eaton, S.L.Gaffen, S.S.Swain, R.M.Locksley, T.Randall, L.Haynes and A.M.Cooper. Nature Immunology. 2007 Apr;8(4):369-77. doi:10.1038/ni1449.PMID: 17351619

IL-12p40, an inherently agonistic cytokine.
A.M.Cooper and S.A.Khader. Trends in Immunology. 2007 Jan 28(1): 33-8. doi: 10.1016/j.it.2006.11.002. PMID: 17126601

Interleukin-12 and tuberculosis: an old story revisited.
A.M.Cooper, A.Solache and S.A.Khader. Curr Opin Immunol. 2007 Aug; 19(4): 441–447. doi: 10.1016/j.coi.2007.07.004.PMID: 17702558